In vivo Adventitious Agent Assays
The test article is inoculated into a range of animal species which increases the probability of detection of adventitious viral contaminants. A combination of embryonated eggs, adult mice and suckling mice are generally used with guinea pigs, rabbits and other species included if appropriate. Animals are observed over a 28 day period for signs of ill health.
These assays detect the presence of viral contaminants but do not identify the nature of the contaminant. Any positive results would require further investigation.
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