Dr Colin J McInnes
Moredun Research Institute
Pentlands Science Park
Midlothian EH26 0PZ
Colin McInnes is currently Head of Vaccines and Diagnostics at Moredun. Colin moved to Moredun over 20 years ago from Glasgow University where he had obtained his PhD. He joined a group working to develop techniques and reagents to study the ovine immune response to infection. In 2003 he became a principal research scientist at Moredun specialising in parapoxvirus infections of ruminants and wildlife. His group was the first to characterise the poxvirus responsible for the deaths of red squirrels, a major contributory factor in their decline within the UK.
- Developing better diagnostics and control measures for parapoxvirus infections of livestock
- Understanding the epidemiology of squirrelpox virus infection in grey squirrels
- Investigating the feasibility of producing a vaccine against squirrelpox virus in order to protect red squirrels
Selected Key Publications
- Entrican, G., Wattegedera S. R., Chui M., Oemar L., Rocchi M., & McInnes C. 2002. Gamma Interferon Fails To Induce Expression of Indoleamine 2,3-Dioxygenase and Does Not Control the Growth of Chlamydophila abortus in BeWo Trophoblast Cells. Infection and Immunity. 70(5):2690 - 2693.
- Wood, A. R., & McInnes C. J. 2003. Transcript mapping of the 'early' genes of Orf virus. Journal of General Virology. 84(11):2993 - 2998.
- Clark, C., McIntyre P. G., Evans A., McInnes C. J., & Lewis-Jones S. 2005. Human sealpox resulting from a seal bite: confirmation that sealpox virus is zoonotic. British Journal of Dermatology. 152(4):791 - 793.
- McInnes, C. J., Deane D., Haig D., Percival A., Thomson J., & Wood A. R. 2005. Glycosylation, disulfide bond formation, and the presence of a WSXWS-like motif in the Orf virus GIF protein are critical for maintaining the integrity of binding to ovine granulocyte-macrophage colony-stimulating factor and Interleukin-2. Journal of Virology. 79(17):11205 - 11213.
- McInnes, C. J., Wood A. R., Thomas K., Sainsbury A. W., Gurnell J., Dein F. J., et al. 2006. Genomic characterization of a novel poxvirus contributing to the decline of the red squirrel (Sciurus vulgaris) in the UK. Journal of General Virology. 87(8):2115 - 2125.
- Deane, D., Ueda N., Wise L. M., Wood A. R., Percival A., Jepson C., et al. 2009. Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins. Journal of General Virology. 90(4):970 - 977.
- McInnes, C. J., Coulter L., Dagleish M. P., Fiegna C., Gilray J., Willoughby K., et al. 2009. First cases of squirrelpox in red squirrels (Sciurus vulgaris) in Scotland. The Veterinary Record. 164(17):528-531.
- Sonvico, F., Colombo G., Gallina L., Bortolotti F., Rossi A., McInnes C. J., et al. 2009. Therapeutic paint of Cidofovir/Sucralfate gel combination topically administered by spraying for treatment of orf virus Infections. The AAPS Journal. 11(2):242 - 249.
- Hautaniemi, M., Ueda N., Tuimala J., Mercer A. A., Lahdenpera J., & McInnes C. J. 2010. The genome of Pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain. Journal of General Virology. 91():1560-1576.
- Wattegedera, S. R., Watson D. M., Hope J. C., Kaiser P., Sales J., McInnes C. J., et al. 2010. Relative quantitative kinetics of interferon-gamma and interleukin-10 mRNA and protein production by activated ovine peripheral blood mononuclear cells. Veterinary Immunology and Immunopathology. 136(1-2):34-42.
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