Professor Gary Entrican
Moredun Research Institute
Pentlands Science Park
Midlothian EH26 0PZ
Gary Entrican is a Principal Research Scientist at Moredun and holds an Honorary Professorship within the College of Medicine and Veterinary Medicine, University of Edinburgh. He is also Honorary Clinical Associate Professor within the College of Medical, Veterinary and Life Sciences at University of Glasgow.
He graduated with BSc Hons in Immunology from University of Glasgow, where he also conducted his PhD in Immunology. He joined Moredun in 1986 working on immune regulation in sheep and has applied his immunological skills to studies on causes of infectious abortion in sheep, initially on Border Disease Virus and more recently on Chlamydia abortus.
Gary's immunological skills are in the areas of ruminant cellular immunology, cytokine biology and the understanding of host-pathogen interactions during infection. The ultimate aim of his research is to identify immunological correlates of protection that underpin vaccine design and implementation of disease control strategies. He has established competitively-funded research links with colleagues at University of Edinburgh. He led a BBSRC/Bio-Rad AbD Serotec-funded Industrial Partnership Award on identification of immune correlates in sheep and cattle with The Roslin Institute at The University of Edinburgh. The outputs of this project were summarised in a webinar delivered under the auspices of Bio-Rad AbD Serotec in July 2015. This webinar is now available here
Gary was appointed Chair of the International Union of Immunological Societies (IUIS) Veterinary Immunology Committee (VIC) in 2013. This committee unites the global veterinary immunology community to create a network of expertise, and also supports meetings and workshops. Further information about IUIS VIC can be found here.
Gary is a member of the Steering Committee of the BBSRC UK Veterinary Vaccinology Research Network, which aims to facilitate collaborations and formulate strategies that address unmet needs in veterinary vaccine development.
- Investigation of innate and adaptive immune responses to Chlamydia abortus infection for implementation of disease prevention and control. Scottish GovernmentRESAS Programme Funding, Theme 6 (2011-16).
- Inflammasome activation in ruminant cells infected withChlamydia abortus. BBSRC/Zoetis CASE PhD Studentship (Laura Doull) within EBRC and University of Edinburgh (2011-15). Collaborative project with Roslin Institute (Prof Liz Glass).
- Neonatal vaccination: role for innate immune cell interactions in BCG vaccination. BBSRC/Zoetis CASE PhD Studentship (Carly Hamilton) within EBRC and University of Edinburgh. Collaborative project with Roslin Institute (Dr Jayne Hope).
- The Role of Dendritic Cells in the Pathogenesis of Bluetongue. WB Martin PhD Studentship (Eleonora Melzi) between Moredun and University of Glasgow (2012-2015). Collaborative project with University of Glasgow (Prof Massimo Palmarini). Other Moredun Investigator: Dr Mara Rocchi.
- Activation of immune responses using ovine lentivirus vaccine vectors. Moredun Scientific PhD Studentship (Rebecca McLean) led by Dr David Griffiths (Moredun) and collaborative with University of Edinburgh (Dr Jayne Hope) (2013-2016).
- Does Chlamydia trachomatis infection have a causative role in miscarriage? Tommy’s Studentship (Sevasti Giakoumelou) with University of Edinburgh (2012-2015). Collaborative Project with QMRI, University of Edinburgh (Dr Andrew Horne and Prof Sarah Howie).
- Understanding inflammatory processes in ovine footrot to inform rational vaccine design. BBSRC Animal Health Research Club (2015-2018). Collaborative Project with University of Nottingham (Dr Sabine Totemeyer, Prof Richard Emes, Dr Tracy Coffey and Dr Jasmeet Kaler).
A selection of Gary's publications can be seen below or for a complete list of papers published since 2010 please click here.
Selected Key Publications
- Entrican, G., Wattegedera S. R., & Griffiths D. J. 2014. Exploiting ovine immunology to improve the relevance of biomedical models. Molecular Immunology. 66(1):68-77.
- Longbottom, D., Livingstone M., Maley S., van der Zon A., Rocchi M., Wilson K., et al. 2013. Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLoS ONE. 8(2):e57950.
- Longbottom, D., Entrican G., Wheelhouse N., Brough H., & Milne C. 2013. Evaluation of the impact and control of enzootic abortion of ewes. The Veterinary Journal. 195(2):257–259.
- Hope, J. C., Sopp P., Wattegedera S., & Entrican G. 2011. Tools and reagents for caprine immunology. Small Ruminant Research. 103(1):23-27.
- Entrican, G., Wheelhouse N., Wattegedera S. R., & Longbottom D. 2012. New challenges for vaccination to prevent chlamydial abortion in sheep. Comparative Immunology, Microbiology and Infectious Diseases. 35(3):271–276.
- Entrican, G., & Lunney J. K. 2012. Veterinary Immunology Committee Toolkit Workshop 2010: Progress and Plans. Veterinary Immunology and Immunopathology. 148(1-2):197-201.
- Rocchi, M. S., Wattegedera S. R., Frew D., Entrican G., Huntley J. F., & McNeilly T. N. 2011. Identification of CD4+CD25 high Foxp3+ T cells in ovine peripheral blood. Veterinary Immunology and Immunopathology. 144(1-2):172-177.
- Rocchi, M. S., Bartley P. M., Inglis N. F., Collantes-Fernandez E., Entrican G., Katzer F., et al. 2011. Selection of Neospora caninum antigens stimulating bovine CD4+ve T cell responses through immuno-potency screening and proteomic approaches. Veterinary Research. 42(1):91.
- Shaw, J. L. V., Fitch P., Cartwright J., Entrican G., Schwarze J., Critchley H. O. D., et al. 2011. Lymphoid and myeloid cell populations in the non-pregnant human Fallopian tube and in ectopic pregnancy. Journal of Reproductive Immunology. 89(14):84-91.
- Howie, S. E. M., Horner P. J., Horne A. W., & Entrican G. 2011. Immunity and vaccines against sexually transmitted Chlamydia trachomatis infection. Current Opinion in Infectious Diseases. 24(1):56 - 61.
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