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Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Published: 2017

Authors:

  • LaDeana W. Hillier

  • Eric S. Loker

  • Patrick Minx

  • Nithya Raghavan

  • Laurence Rodrigues do Amaral

  • Juliana G. Assis

  • Elio Hideo Baba

  • Olga L. Baron

  • Christopher J. Bayne

  • Utibe Bickham-Wright

  • Kyle K. Biggar

  • Michael Blouin

  • Bryony C. Bonning

  • Chris Botka

  • Joanna M. Bridger

  • Katherine M. Buckley

  • Sarah K. Buddenborg

  • Roberta Lima Caldeira

  • Julia Carleton

  • Omar S. Carvalho

  • Maria G. Castillo

  • Iain W. Chalmers

  • Mikkel Christensens

  • Sandra Clifton

  • Celine Cosseau

  • Christine Coustau

  • Richard M. Cripps

  • Yesid Cuesta-Astroz

  • Scott F. Cummins

  • Leon di Stefano

  • Nathalie Dinguirard

  • David Duval

  • Scott Emrich

  • Cédric Feschotte

  • Rene Feyereisen

  • Peter FitzGerald

  • Catrina Fronick

  • Lucinda Fulton

  • Richard Galinier

  • Sandra G. Gava

  • Michael Geusz

  • Kathrin K. Geyer

  • Gloria I. Giraldo-Calderón

  • Matheus de Souza Gomes

  • Michelle A. Gordy

  • Benjamin Gourbal

  • Christoph Grunau

  • Patrick C. Hanington

  • Karl F. Hoffmann

  • Daniel Hughes

  • Judith Humphries

  • Daniel J. Jackson

  • Liana K. Jannotti-Passos

  • Wander de Jesus Jeremias

  • Susan Jobling

  • Bishoy Kamel

  • Aurélie Kapusta

  • Satwant Kaur

  • Joris M. Koene

  • Andrea B. Kohn

  • Dan Lawson

  • Scott P Lawton

  • Di Liang

  • Yanin Limpanont

  • Sijun Liu

  • Anne E. Lockyer

  • TyAnna L. Lovato

  • Fernanda Ludolf

  • Vince Magrini

  • Donald P. McManus

  • Monica Medina

  • Milind Misra

  • Guillaume Mitta

  • Gerald M. Mkoji

  • Michael J. Montague

  • Cesar Montelongo

  • Leonid L. Moroz

  • Monica C. Munoz-Torres

  • Umar Niazi

  • Leslie R. Noble

  • Francislon S. Oliveira

  • Fabiano S. Pais

  • Anthony T. Papenfuss

  • Rob Peace

  • Janeth J. Pena

  • Janeth J. Pena

  • Emmanuel A. Pila

  • Titouan Quelais

  • Brian J. Raney

  • Jonathan P. Rast

  • David Rollinson

  • Izinara C. Rosse

  • Bronwyn Rotgans

  • Edwin J. Routledge

  • Kathryn M. Ryan

  • Larissa L. S. Scholte

  • Kenneth B. Storey

  • Martin Swain

  • Jacob A. Tennessen

  • Chad Tomlinson

  • Damian L. Trujillo

  • Emanuela V. Volpi

  • Anthony J. Walker

  • Tianfang Wang

  • Ittiprasert Wannaporn

  • Wesley C. Warren

  • Xiao-Jun Wu

  • Timothy P. Yoshino

  • Mohammed Yusuf

  • Si-Ming Zhang

  • Min Zhao

  • Richard K. Wilson

Abstract:

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization’s goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

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