Published: 2017
DOI: 10.1038/ncomms15451
Authors:
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LaDeana W. Hillier
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Eric S. Loker
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Patrick Minx
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Nithya Raghavan
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Laurence Rodrigues do Amaral
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Juliana G. Assis
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Elio Hideo Baba
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Olga L. Baron
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Christopher J. Bayne
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Utibe Bickham-Wright
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Kyle K. Biggar
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Michael Blouin
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Bryony C. Bonning
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Chris Botka
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Joanna M. Bridger
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Katherine M. Buckley
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Sarah K. Buddenborg
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Roberta Lima Caldeira
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Julia Carleton
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Omar S. Carvalho
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Maria G. Castillo
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Iain W. Chalmers
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Mikkel Christensens
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Sandra Clifton
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Celine Cosseau
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Christine Coustau
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Richard M. Cripps
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Yesid Cuesta-Astroz
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Scott F. Cummins
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Leon di Stefano
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Nathalie Dinguirard
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David Duval
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Scott Emrich
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Cédric Feschotte
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Rene Feyereisen
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Peter FitzGerald
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Catrina Fronick
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Lucinda Fulton
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Richard Galinier
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Sandra G. Gava
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Michael Geusz
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Kathrin K. Geyer
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Gloria I. Giraldo-Calderón
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Matheus de Souza Gomes
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Michelle A. Gordy
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Benjamin Gourbal
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Christoph Grunau
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Patrick C. Hanington
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Karl F. Hoffmann
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Daniel Hughes
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Judith Humphries
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Daniel J. Jackson
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Liana K. Jannotti-Passos
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Wander de Jesus Jeremias
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Susan Jobling
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Bishoy Kamel
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Aurélie Kapusta
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Satwant Kaur
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Joris M. Koene
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Andrea B. Kohn
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Dan Lawson
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Scott P Lawton
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Di Liang
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Yanin Limpanont
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Sijun Liu
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Anne E. Lockyer
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TyAnna L. Lovato
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Fernanda Ludolf
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Vince Magrini
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Donald P. McManus
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Monica Medina
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Milind Misra
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Guillaume Mitta
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Gerald M. Mkoji
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Michael J. Montague
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Cesar Montelongo
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Leonid L. Moroz
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Monica C. Munoz-Torres
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Umar Niazi
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Leslie R. Noble
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Francislon S. Oliveira
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Fabiano S. Pais
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Anthony T. Papenfuss
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Rob Peace
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Janeth J. Pena
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Janeth J. Pena
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Emmanuel A. Pila
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Titouan Quelais
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Brian J. Raney
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Jonathan P. Rast
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David Rollinson
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Izinara C. Rosse
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Bronwyn Rotgans
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Edwin J. Routledge
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Kathryn M. Ryan
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Larissa L. S. Scholte
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Kenneth B. Storey
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Martin Swain
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Jacob A. Tennessen
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Chad Tomlinson
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Damian L. Trujillo
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Emanuela V. Volpi
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Anthony J. Walker
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Tianfang Wang
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Ittiprasert Wannaporn
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Wesley C. Warren
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Xiao-Jun Wu
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Timothy P. Yoshino
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Mohammed Yusuf
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Si-Ming Zhang
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Min Zhao
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Richard K. Wilson
Abstract:
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization’s goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.