Dr Bill Golde leads the viral immunology group designing and testing vaccine for cattle sheep and pigs. He established and grows the new swine portfolio at Moredun, and manages the newly established Pentlands Immunologics to prepare and distribute immune reagents for research in livestock species.
Dr. Bill Golde trained in basic immunology at Yale University and the University of Colorado studying T cell responses in mice. After finishing his PhD in the Kappler /Marrack lab, he completed postdoctoral training in molecular virology, studying HTLV 1 and 2.
He entered the field of vaccine research joining the Centers for Disease Control and then Stony Brook University, working on a vaccine for Lyme disease, which was licensed for both human and canine. For the following 17 years, Dr. Golde led the immunology laboratory at the USDA’s Plum Island Animal Disease Center (PIADC), investigating immune responses of swine and cattle to foot-and-mouth disease virus (FMDV) infection.
The Golde lab has developed new technologies to more closely track immune responses of swine and cattle, and using that information, have now designed new vaccine strategies to broaden the immune response to vaccination by targeting T cell responses.
In 2016, he moved to Edinburgh, Scotland to join the Moredun Research Institute. The techniques developed at USDA are now being applied to other critical diseases of cattle, sheep and swine.
Dr. Golde’s lab continues to expand and refine these technologies developed for livestock, enhancing vaccine design and the assessment of vaccine performance.
At the Moredun Research Institute, the Golde Lab applies the techniques developed at USDA to other critical diseases of cattle, sheep and swine including porcine reproductive and respiratory syndrome virus (PRRSV), African Swine Fever (ASF) virus, bovine herpes virus (BHV-1) and bovine respiratory syncytial virus (BRSV), while continuing work on new FMDV vaccines.
In collaboration with Søren Buus’ lab at University of Copenhagen, work continues to generate and characterize MHC tetramers for use in analysing T cell responses in swine and cattle, critical tools for analysing the immune response in these species. The lab is funded to design and test new vaccines for Streptococcus suis with Intervacc and the Swedish Veterinary Institute; FMDV, with Tiba Biotech in Boston, USA; PRRSV with Chulalongkorn University in Bankok, Thailand; and the viruses that contribute to the bovine respiratory disease complex, BHV-1 and BRSV with colleagues at Moredun.
In addition, he and colleagues at Moredun together with New England Animal Health in Vermont, USA, began Pentlands Immunologics, which was established to provide quality, validated immune reagents to the livestock research community.