Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS

Authors:

• Jeffery D. Zwicker

• David Smith

• Alfredo J. Guerra

• Jacob R. Hitchens

• Nicole Haug

• Steve Vander Roest

• Pil Lee

• Bo Wen

• Duxin Sun

• Lu Wang

• Richard F. Keep

• Jianming Xiang

• Vern B. Carruthers

• Scott D. Larsen