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Gamma Interferon Fails To Induce Expression of Indoleamine 2,3-Dioxygenase and Does Not Control the Growth of Chlamydophila abortus in BeWo Trophoblast Cells

Published: 2002

Research Scotland: 20.500.12594/11819


  • Gary Entrican

  • Sean Wattegedera

  • Michelle Chui

  • Lyn Oemar

  • Mara Rocchi

  • Colin McInnes

Is Part of:

Infection and Immunity, 70, 5, pp2690-2693.



The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of
Chlamydophila abortus
, in contrast to effects observed in HeLa cells treated with gamma interferon.

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